Publications

Bell A.F., Rawat R., Novichenok P., Nair P.A., Sivaraman A., Parikh S.L., Tonge P.J. (2007) Structure and Dynamics of the NADH cofactor in complex with the Enoyl Reductase from Mycobacterium tuberculosis probed by Raman Spectroscopy, Journal of the American Chemical Society 129, 6425-6431 (pdf).

Zhou G.C., Parikh S.L., Tyler P.C., Evans G.B., Furneaux, R.H., Zubkova O.V., Benjes P.A., Schramm V.L. (2004) Inhibitors of ADP-Ribosylating Bacterial Toxins Based on Oxacarbenium Ion Character at their Transition States, Journal of the American Chemical Society 126, 5960-5968 (pdf).

Parikh S.L., and Schramm V.L. (2004) Transition State Structure for ADP-Ribosylation of eukaryotic Elongation Factor 2 Catalyzed by Diphtheria Toxin, Biochemistry 43, 1204-1212 (pdf).

Bell A.F., Feng Y., Hofstein H.A., Parikh S.L., Wu J., Rudolph M.J., Kisker C., Whitty A., Tonge P.J. (2002) Stereoselectivity of Enoyl-CoA Hydratase Results from Preferential Activation of One of Two Bound Substrate Conformers, Chemistry & Biology 9, 1247-1255 (pdf).

Parikh S.L., Xiao G., Tonge P.J. (2000) Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis, by Isoniazid and Triclosan, Biochemistry 39, 7645-7650. (accelerated publication) (pdf).

Parikh S.L., Moynihan D.P., Xiao G., Tonge P.J. (1999) The Role of Tyrosine 158 and Lysine 165 in the Catalytic Mechanism of InhA, the Enoyl-ACP Reductase from Mycobacterium Tuberculosis, Biochemistry 38, 13623-13634 (pdf).

Stewart M.J., Parikh S.L., Xiao G., Tonge P.J, Kisker C. (1999) Structural Basis and Mechanism of Enoyl-Reductase Inhibition by Triclosan, Journal of Molecular Biology 290, 859-865 (pdf).



Presentations

Parikh S.L. and Schramm V.L., “Transition State Structure for ADP-Ribosylation of eEF-2 by Diphtheria Toxin”. Gordon Isotope Effects Conference, Ventura, California, January 2004.

Parikh S.L. and Schramm V.L., “Transition State Structure for ADP-Ribosylation of eEF-2 by Diphtheria Toxin”. American Chemical Society – National Meeting, NY, New York, September 2003.

Parikh S.L. and Schramm V.L., “Transition State Analysis for ADP-Ribosylation of eEF-2 by Diphtheria Toxin”. International Isotope Effects Conference, Uppsala, Sweden, June 2003.

Parikh S.L. and Schramm V.L., “Transition State Inhibitors for ADP-Ribosylating Toxin”. American Chemical Society – National Meeting, Boston, Massachusetts, August 2002.

Parikh S.L. and Schramm V.L., “Transition State Analysis of Diphtheria Toxin”. 17th Annual Enzyme Mechanism Conference, Marco Island, Florida, January 2001.

Parikh S.L. and Tonge P.J., “Probing the Mechanism of Inhibition of InhA, the Enoyl-ACP Reductase, from Mycobacterium tuberculosis, by Isoniazid and Triclosan.” American Society of Microbiology – Tuberculosis 2000, New York, New York, June 2000

Parikh S.L. and Tonge P.J., “Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium Tuberculosis, by Triclosan”. Bioorganic - Gordon Research Conference, Andover, New Hampshire, June 1999.

Parikh S.L., and Tonge P.J., “Investigation into the Role of Tyrosine 158 and Lysine 165 in the Reaction Catalyzed by InhA, the Enoyl-ACP Reductase from Mycobacterium Tuberculosis”. 16th Annual Enzyme Mechanism Conference, Napa, California, January 1999.